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Timely commentary on healthcare in general, cancer in particular.

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Tag Archives: Keytruda

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Dr. Hossein Borghaei (Pt 2): Reflecting on Progress & Future Directions in Immunotherapy

Drs. Hossein Borghaei and host Jack West discuss long term outcomes in lung cancer with immunotherapy, potential utility of IO combinations, and when we can consider patients doing well on immunotherapy as cured if doing well beyond 5 years. (26:22)

July 24, 2019 by BeaconMedIC Posted in West Wind Podcast Tagged #LCSM, Beacon Medical Interchange, Cancer, City of Hope, City of Hope Comprehensive Cancer Center, Education, Fox Chase Cancer Center, Health, Hossein Borghaei, Howard (Jack) West, immunotherapy, IO combination, Jack West, Keytruda, lung cancer, Medicine, nivolumab/ipilimumab, Oncology, pembrolizumab, Science, TMB, Tumor Mutational Burden, West Wind, West Wind Podcast

Dr. Jack West: Why the Broader FDA Approval of First Pembrolizumab Monotherapy based on KEYNOTE-042 is an Invitation to Inferior Care in Advanced NSCLC

Dr. Jack West reviews why the new FDA approval of first line pembrolizumab monotherapy for the 1-49% PD-L1 subgroup won on a technicality and now offers a clearly inferior choice compared to far better existing standards for patients with low tumor PD-L1. (20:08)

April 19, 2019 by BeaconMedIC Posted in West Wind Podcast Tagged Advanced NSCLC, Beacon Medical Interchange, Cancer, chemo-immunotherapy, chemo/radiation, City of Hope, City of Hope Comprehensive Cancer Center, Education, Health, Howard (Jack) West, immunotherapy, Jack West, KEYNOTE-024, KEYNOTE-042, Keytruda, Medicine, monotherapy, non-small cell lung cancer, Oncology, PD-L1, pembrolizumab, Science, stage IV, West Wind, West Wind Podcast

Weighing the clinical significance of new clinical trial results with immunotherapy in stage III and IV NSCLC

Drs. Jack West & Corey Langer debate the criteria for adopting early clinical data as practice-changing as immunotherapy trials in locally advanced & metastatic NSCLC are reported. (19:05)

April 9, 2019 by BeaconMedIC Posted in West Wind Podcast Tagged Beacon Medical Interchange, Cancer, chemo-immunotherapy, City of Hope, City of Hope Comprehensive Cancer Center, Corey Langer, durvalumab, Education, Health, Howard (Jack) West, IMFINZI, immunotherapy, Jack West, KEYNOTE-021g, KEYNOTE-189, Keytruda, locally advanced NSCLC, Medicine, metastatic NSCLC, Oncology, overall survival, PACIFIC Trial, pembrolizumab, progression-free survival, Science, stage 3 NSCLC, stage 4 NSCLC, trial endpoints, University of Pennsylvania, West Wind, West Wind Podcast

Dr. David Spigel, Part 2: Identifying the Optimal Duration for Immunotherapy in Responding Patients with Advanced Lung Cancer

Dr. Jack West interviews Dr. David Spigel of Sarah Cannon Research Institute on the challenges of conducting clinical trials and delivering increasingly complex patient care, along with the possible future role of artificial intelligence and telemedicine. (20:36)

March 8, 2019 by BeaconMedIC Posted in West Wind Podcast Tagged Advanced NSCLC, Beacon Medical Interchange, Cancer, City of Hope Cancer Center, City of Hope Comprehensive Cancer Center, complete response, cost of therapy nivolumab, David Spigel, depth of response, duration, Education, Health, Howard (Jack) West, immune checkpoint inhibitor, immunotherapy, Jack West, Keytruda, lung cancer, Medicine, Oncology, Opdivo, pembrolizumab, Sarah Cannon Cancer Center, Sarah Cannon Research Institute, Science, side effects, West Wind, West Wind Podcast

Top 5 Most Influential Trial Findings in Lung Cancer Management in 2018 (BMIC-073)

Dr. Jack West summarizes his list of the top 5 most influential trials in lung cancer that reported results in 2018, including why they matter. (13:27)

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December 28, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged atezolizumab, Beacon, Beacon Medical Interchange, Cancer, chemoradiation, chemotherapy, consolidation, durvalumab, Education, EGFR mutation, first-line, gefitinib, H. Jack West, Health, IMFINZI, immunotherapy, Iressa, Jack West, KEYNOTE-189, KEYNOTE-407, Keytruda, Medicine, nab-paclitaxel, NEJ009, non-small cell lung cancer, NSCLC, Oncology, PACIFIC Trial, paclitaxel, pembrolizumab, pemetrexed, Science, SCLC, small cell lung cancer, Tecentriq, The Beacon, The Beacon Podcast

Pembrolizumab for Patients with Advanced NSCLC and a Performance Status (PS) of 2: Results of the PePS2 Trial (BMIC-067)

Dr. Jack West summarizes new information presented at ESMO 2018 on the PePS2 trial of pembrolizumab (Keytruda) in patients with advanced NSCLC performance status (PS) of 2, which demonstrated favorable efficacy and no concerning challenges with toxicity in this population. (4:12)

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November 16, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged Beacon, Beacon Medical Interchange, Cancer, Education, ESMO 2018, Gary Middleton, H. Jack West, Health, immune checkpoint inhibitor, immunotherapy, Jack West, Keytruda, Medicine, non-small cell lung cancer, NSCLC, Oncology, PD-L1, pembrolizumab, PePS2, performance status 2, PS2, re-challenge, Science, The Beacon, The Beacon Podcast

Long-Term Management of Patients Doing Well on Immunotherapy for Advanced NSCLC: Insights from KEYNOTE-010 (BMIC-066)

Dr. Jack West reviews longitudinal outcomes for patients on the KEYNOTE-010 trial of pembrolizumab (Keytruda) vs. docetaxel as 2nd line therapy for advanced NSCLC, with helpful new info on those completing 2 years of pembro & implications for practice. (8:03)

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November 14, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged Beacon, Beacon Medical Interchange, Cancer, duration of therapy, Education, ESMO 2018, H. Jack West, Health, immune checkpoint inhibitor, immunotherapy, Jack West, KEYNOTE-010, Keytruda, long-term, Medicine, non-small cell lung cancer, NSCLC, Oncology, PD-L1, pembrolizumab, re-challenge, Roy Herbst, Science, The Beacon, The Beacon Podcast

Immunotherapy with Pembrolizumab in Metastatic Prostate Cancer: Highlights in GU Oncology from ASCO 2018 (BMIC-055)

Dr. Daniel Goldstein summarizes key data in genitourinary oncology from ASCO 2018, including new results on pembrolizumab (Keytruda) for metastatic prostate cancer, asking whether it could find a place as treatment for a subset of these patients. (2:17)

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August 17, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged ASCO 2018, Beacon, Beacon Medical Interchange, Cancer, checkpoint inhibitor, Daniel Goldstein, De Bono, Education, genitourinary cancer, GU oncology, H. Jack West, Health, immunotherapy, Jack West, Keytruda, Medicine, metastatic prostate cancer, Oncology, pembrolizumab, prostate cancer, Rabin Medical Center, Science, The Beacon, The Beacon Podcast, University of North Carolina

Pembrolizumab in First Line Clear Cell RCC & the Evolving Role of Immunotherapy in Metastatic RCC: Highlights from ASCO 2018 (BMIC-053)

Dr. Daniel Goldstein discusses the results of a trial of first line pembrolizumab (Keytruda) as first line therapy for patients with metastatic clear cell renal cell carcinoma and the implications for the future role of immunotherapy in RCC. (3:18)

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August 13, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged ASCO 2018, Beacon, Beacon Medical Interchange, Cancer, clear cell RCC, Daniel Goldstein, Education, H. Jack West, Health, immunotherapy, Jack West, Keytruda, kidney cancer, McDermott, Medicine, metastatic renal cell carcinoma, Oncology, pembrolizumab, Rabin Medical Center, Science, The Beacon, The Beacon Podcast, University of North Carolina

Could Immunotherapy Replace Neoadjuvant Chemo for Muscle-Invasive Transitional Cell Carcinoma? Highlights from ASCO 2018 (BMIC-047)

Dr. Daniel Goldstein reviews highlights in bladder cancer from ASCO 2018, including important studies evaluating the efficacy of neoadjuvant immunotherapy instead of chemotherapy for muscle-invasive transitional cell carcinoma of the bladder? (3:34)

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July 27, 2018 by BeaconMedIC Posted in The Beacon Podcast Tagged ASCO 2018, atezolizumab, Beacon, Beacon Medical Interchange, Cancer, Daniel Goldstein, Education, H. Jack West, Health, Jack West, Keytruda, Medicine, muscle-invasive bladder cancer, Oncology, pembrolizumab, Rabin Medical Center, Science, TCC, Tecentriq, The Beacon, The Beacon Podcast, transitional cell carcinoma, University of North Carolina

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