immunotherapy Archives – Beacon Medical Interchange

Dr. Patrick Forde, on the Practical Benefits and Clinical Promise of Neoadjuvant Therapy and Pathology Assessment in Early NSCLC | BTJ-022

Hosts Jack West & Charu Aggarwal speak with immunotherapy expert Dr. Patrick Forde about unique advantages of the pre-operative platform for systemic therapy, especially immunotherapy, in early stage cancer & pathologic response assessment from surgery. (41:04)

Audio Podcast

Drs. Jack West and Charu Aggarwal: New Data on Liquid Biopsies, Tumor Mutational Burden, and Choosing Optimal Systemic Therapy Today

Dr. Charu Aggarwal from University of Pennsylvania Abramson Cancer Center joins Dr. Jack West to discuss new data on plasma-based testing for tumor mutational burden (TMB) & the current state of liquid biopsies, TMB, & immunotherapy-based options today. (36:57)

Dr. Tim Gilligan (Pt. 1): Developing a Focus on Genitourinary Oncology

Host Jack West, MD speaks with Timothy Gilligan, MD, FASCO from Cleveland Clinic, reviewing his path into medicine & genitourinary oncology, then discussing new challenges in testicular, bladder, and prostate cancer management. (30:56)

Dr. Hossein Borghaei (Pt 2): Reflecting on Progress & Future Directions in Immunotherapy

Drs. Hossein Borghaei and host Jack West discuss long term outcomes in lung cancer with immunotherapy, potential utility of IO combinations, and when we can consider patients doing well on immunotherapy as cured if doing well beyond 5 years. (26:22)

Dr. Jack West on New Data Combining Radiation with Immunotherapy in Advanced NSCLC: A Brief Critical Review

Dr. Jack West provides a brief summary of key findings & limitations of two new papers just out in JAMA Oncology (Theelen et al & Bauml et al.) that evaluate the potential benefit of preceding immunotherapy with radiation in patients with advanced NSCLC. (18:00)

Dr. Jack West: Why the Broader FDA Approval of First Pembrolizumab Monotherapy based on KEYNOTE-042 is an Invitation to Inferior Care in Advanced NSCLC

Dr. Jack West reviews why the new FDA approval of first line pembrolizumab monotherapy for the 1-49% PD-L1 subgroup won on a technicality and now offers a clearly inferior choice compared to far better existing standards for patients with low tumor PD-L1. (20:08)

Weighing the clinical significance of new clinical trial results with immunotherapy in stage III and IV NSCLC

Drs. Jack West & Corey Langer debate the criteria for adopting early clinical data as practice-changing as immunotherapy trials in locally advanced & metastatic NSCLC are reported. (19:05)

Dr. David Spigel, Part 2: Identifying the Optimal Duration for Immunotherapy in Responding Patients with Advanced Lung Cancer

Dr. Jack West interviews Dr. David Spigel of Sarah Cannon Research Institute on the challenges of conducting clinical trials and delivering increasingly complex patient care, along with the possible future role of artificial intelligence and telemedicine. (20:36)

Top 5 Most Influential Trial Findings in Lung Cancer Management in 2018 (BMIC-073)

Dr. Jack West summarizes his list of the top 5 most influential trials in lung cancer that reported results in 2018, including why they matter. (13:27)

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What does the CheckMate-331 trial of nivolumab vs. chemo for relapsed SCLC tell us? (BMIC-072)

Dr. Jack West reviews the trial design, key results, and implications of the CheckMate-331 trial of nivolumab (Opdivo) vs. standard chemotherapy for relapsed small cell lung cancer. (8:57)